This curated selection of articles provides a comprehensive overview of the latest strategies in Alzheimer's disease (AD) treatment and management. It examines the role of amyloid-targeted therapies, the complex interplay between amyloid, tau, and cerebral small vessel disease, and the clinical significance of amyloid-related imaging abnormalities (ARIA). Additionally, the collection explores innovative therapeutic options such as therapeutic plasma exchange and blood derivatives therapy, while also considering the evolution of clinical care pathways and practice guidelines for AD. These studies collectively offer valuable insights into the current successes and future directions of AD therapeutics and diagnostics.